Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances

  title={Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances},
  author={Masayoshi Arai and Chisu Han and Yoshi Yamano and Andi Setiawan and Motomasa Kobayashi},
  journal={Journal of Natural Medicines},
A new aaptamine class alkaloid, designated 2-methoxy-3-oxoaaptamine (1), together with seven known aaptamines (2–8) were isolated from a marine sponge of Aaptos sp. as anti-mycobacterial substances against active and dormant bacilli. The chemical structure of 1 was determined on the basis of spectroscopic analysis. Compound 1 was anti-mycobacterial against Mycobacterium smegmatis in both active growing and dormancy-inducing hypoxic conditions with a minimum inhibitory concentration (MIC) of 6… CONTINUE READING