AZT-resistant foamy virus.

  title={AZT-resistant foamy virus.},
  author={Benedikt Kretzschmar and Ali Nowrouzi and Maximilian Hartl and Kathleen G{\"a}rtner and Tatiana Wiktorowicz and Ottmar Herchenr{\"o}der and Sylvia Kanzler and Wolfram W Rudolph and Ayalew Mergia and Birgitta M. W{\"o}hrl and Axel Rethwilm},
  volume={370 1},
Azidothymidine (AZT) is a reverse transcriptase (RT) inhibitor that efficiently blocks the replication of spumaretroviruses or foamy viruses (FVs). To more precisely elucidate the mechanism of action of the FV RT enzyme, we generated an AZT-resistant FV in cell culture. Biologically resistant virus was obtained for simian foamy virus from macaque (SFVmac), which was insensitive to AZT concentrations of 1 mM, but not for FVs derived from chimpanzees. Nucleotide sequencing revealed four non… CONTINUE READING