AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

Abstract

The replication of simian foamy virus from macaques can be inhibited by the nucleoside reverse transcriptase inhibitor azidothymidine (AZT, zidovudine). Four substitutions in the protease-reverse transcriptase (PR-RT) protein (K211I, I224T, S345T, E350K) are necessary to obtain highly AZT resistant and fully replication competent virus. AZT resistance is… (More)
DOI: 10.1186/s12977-015-0147-7

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@inproceedings{Schneider2015AZTRA, title={AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase}, author={Anna R. Schneider and Kristian Schweimer and Paul R{\"o}sch and Birgitta M. W{\"o}hrl}, booktitle={Retrovirology}, year={2015} }