AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression

@article{Chen2013AZTAE,
  title={AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression},
  author={P. Chen and Y. Liu and Y. Sun and Che Chen and Yongmei Qi and Y. Zhang},
  journal={Pharmaceutical Biology},
  year={2013},
  volume={51},
  pages={1586 - 1591}
}
  • P. Chen, Y. Liu, +3 authors Y. Zhang
  • Published 2013
  • Biology, Medicine
  • Pharmaceutical Biology
  • Abstract Context: Previous studies have demonstrated that both 3′-azido-3′-deoxythymidine (AZT) and emodin, a traditional chemotherapy agent, can inhibit the growth of many types of cancer cells. Objective: This study aimed to evaluate the effect of AZT and emodin on adriamycin-resistant human chronic myelogenous leukemia (K562/ADM) cells, determine the expression of multidrug resistance 1 (MDR1) mRNA/p-glycoprotein (p-gp) protein, a protein known to induce resistance to anticancer agents, and… CONTINUE READING
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