AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma.

@article{Huynh2007AZD6244AD,
  title={AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma.},
  author={Hung Quoc Huynh and Pierce Kah Hoe Chow and Kim cheol Soo},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 9},
  pages={
          2468-76
        }
}
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with no effective treatment for most individuals who succumb to this neoplasm. We report that treatment of primary HCC cells with the mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase 1/2 inhibitor AZD6244 (ARRY-142886) plus doxorubicin led to synergistic growth inhibition and apoptosis. In vivo administration of AZD6244, doxorubicin, or the combination of AZD6244 and doxorubicin in mice… CONTINUE READING
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