AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer.

@article{Yang2009AZD6244E,
  title={AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer.},
  author={Shu Yang and Van Chanh Ngo and Guo Bin Lew and Lih Wen Valerie Chong and Swee Shean Lee and Wei Jie Richard Ong and Wei Ling Irene Lam and C. H. Thng and Heng Nung Koong and Hock Soo Ong and Alexander Q. H. Chung and Pierce Kah Hoe Chow and Jonathan W J Lee and Khee Chee Soo and Hung Quoc Huynh},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 9},
  pages={2537-45}
}
Gastric cancer is a deadly disease for which current therapeutic options are extremely limited. Vascular endothelial growth factor receptors and platelet-derived growth factor receptors regulate gastric cancer cell proliferation, invasion, and tumor angiogenesis. In the present study, we report that sorafenib therapy effectively inhibited tumor growth and angiogenesis in tumor xenografts. These were associated with reduction in the phosphorylation of vascular endothelial growth factor receptor… CONTINUE READING