AY-31,906, a novel high ceiling diuretic: characterization of its relative potassium-sparing actions in rats and dogs.

Abstract

AY-31,906, exo-2-amino-4-[(bicyclo[2.2.1]hept-2-yl)amino-N-[[1- methylethyl)amino]carbonyl]-5-pyrimidinesulfonamide, exhibited potent diuretic and natriuretic activity in rats and dogs. After p.o. administration, AY-31,906 was 1.5- and 12.3-times more potent as a natriuretic than furosemide in rats and dogs, respectively, whereas it was 0.5- and 6.1-times… (More)

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Cite this paper

@article{Ackerman1989AY31906AN, title={AY-31,906, a novel high ceiling diuretic: characterization of its relative potassium-sparing actions in rats and dogs.}, author={David Ackerman and Maureen Brady and Anthony Maclean and T. M. Smith}, journal={The Journal of pharmacology and experimental therapeutics}, year={1989}, volume={251 3}, pages={1113-9} }