AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling

@article{Chen2017AXLPZ,
  title={AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling},
  author={Jian Chen and Yifeng Yang and Yu Yang and Peng Zou and Jun Chen and Yongquan He and Sai-Lan Shui and Yan-ru Cui and Ru Feng Bai and Ya-Jun Liang and Yunwen Hu and Biao Jiang and Lu Lu and Xiaoyan Zhang and Jia Liu and Jianqing Xu},
  journal={Nature Microbiology},
  year={2017},
  volume={3},
  pages={302-309}
}
Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain–Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3–9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role of AXL, a TAM family kinase receptor that was initially described as the entry receptor for ZIKV10–22. Here, we show that while genetic ablation of AXL protected primary human… CONTINUE READING

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Zika Virus Targeting in the Developing Brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2017

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