AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer

@inproceedings{Divine2016AXLME,
  title={AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer},
  author={Laura M. Divine and Mai R. Nguyen and Eric H. Meller and Riva A. Desai and Batool Arif and Erinn B. Rankin and Katherine H. Bligard and Cherise Meyerson and Ian Hagemann and Maria Massad and Premal H. Thaker and Andrea R. Hagemann and Carolyn Kay McCourt and Matt Powell and David G. Mutch and Katherine C. Fuh},
  booktitle={Oncotarget},
  year={2016}
}
The receptor tyrosine kinase AXL promotes migration, invasion, and metastasis. Here, we evaluated the role of AXL in endometrial cancer. High immunohistochemical expression of AXL was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade specimens and correlated with worse survival in uterine serous cancer patients. In vitro, genetic silencing of AXL inhibited migration and invasion but had no effect on proliferation of ARK1 endometrial cancer cells. AXL-deficient cells showed… CONTINUE READING

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