AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders

  title={AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders},
  author={Alexandre V. Ivachtchenko and Yan Lavrovsky and Ilya Okun},
  booktitle={Journal of Alzheimer's disease : JAD},
Lack of efficacy of many new highly selective and specific drug candidates in treating diseases with poorly understood or complex etiology, as are many of central nervous system (CNS) diseases, encouraged an idea of developing multi-modal (multi-targeted) drugs. In this manuscript, we describe molecular pharmacology, in vitro ADME, pharmacokinetics in animals and humans (part of the Phase I clinical studies), bio-distribution, bioavailability, in vivo efficacy, and safety profile of the… CONTINUE READING
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