AUX/IAA proteins are active repressors, and their stability and activity are modulated by auxin.

@article{Tiwari2001AUXIAAPA,
  title={AUX/IAA proteins are active repressors, and their stability and activity are modulated by auxin.},
  author={Shiv B. Tiwari and Xiu Jie Wang and Gisela Hagen and Tom J Guilfoyle},
  journal={The Plant cell},
  year={2001},
  volume={13 12},
  pages={2809-22}
}
Aux/IAA genes are early auxin response genes that encode short-lived nuclear proteins with four conserved domains, referred to as I, II, III, and IV. Arabidopsis Aux/IAA proteins repressed transcription on auxin-responsive reporter genes in protoplast transfection assays. Mutations in domain II resulted in increased repression, whereas mutations in domains I and III partially relieved repression. Aux/IAA proteins fused to a heterologous DNA binding domain were targeted to promoters of… CONTINUE READING
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