AUTOIMMUNITY IN PERNICIOUS ANEMIA AND THYROIDITIS: A FAMILY STUDY *
@article{Doniach1965AUTOIMMUNITYIP, title={AUTOIMMUNITY IN PERNICIOUS ANEMIA AND THYROIDITIS: A FAMILY STUDY *}, author={Deborah Doniach and Ivan Maurice Roitt and K. B. Taylor}, journal={Annals of the New York Academy of Sciences}, year={1965}, volume={124} }
The familial occurrence of myxoedema and Hashimoto’s thyroiditis has been well documented (Craig et al . , 1952; Dunning, 1959; Kitchin & Howell-Evans, 1960; Irvine et al., 1961; Hung & Winship, 1963). Thyroid autoantibodies were found by Hall, Owen and Smart (1960) in 22 of 39 siblings of patients with autoimmune thyroid disease and no less than 11 of these had some clinical abnormality of the thyroid gland. I t was concluded that the tendency to thyroid autoimmunity was genetically determined…
88 Citations
Autoimmunity and multiple endocrine abnormalities.
- Medicine, BiologyArchives of internal medicine
- 1972
Binding studies carried out on a patient with chronic lymphocytic thyroiditis, idiopathic adrenal insufficiency, pernicious anemia, and vitiligo suggest that a genetically determined predisposition to develop autoimmune reactions of this type may exist in some individuals.
Autoantibodies in simple atrophic gastritis
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- 1965
Interesting correlations were found between the parietal cell antibodies and such factors as the degree of loss of parietal cells, the severity of the gastric secretory defect, and the presence of thyroid antibodies.
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- Medicine, BiologyBritish journal of haematology
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It is postulated that the presence of autoimmune disease in both sides of the family potentiated a genetic predisposition to autoimmune disease and the offspring developed pernicious anaemia at an unusually early age and had antibodies against several tissues and/or their products including thyroid tissue but no overt thyroid disease.
A population-based study of chronic autoimmune hypothyroidism in Danish twins.
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- 2000
The higher concordance rate in monozygotic compared to dizygotic pairs indicates that genetic factors play a role in the etiology of HT/AT among Caucasian women living in areas with borderline iodine deficiency.
Nonmalignant monoclonal immunoglobulinemia, pernicious anemia and gastric carcinoma. A model of immunologic dysfunction. Report of two cases and review of the literature.
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Since hypocalcaemia is thought to depress gastric function and possibly also the secretion of intrinsic factor (Waters and Murphy, 1963), cases following endocrine disorders should be treated with reserve when conclusions are drawn regarding the nature of juvenile pernicious anaemia.
Pernicious Anaemia as an Autoimmune Disease
- MedicineBritish journal of haematology
- 1972
Over the last 20 years the megaloblastic anaemias has been one ofthe major fields ofresearch in the Department of Haematology at the Royal Postgraduate Medical School under the direction of Professor…
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- Medicine, BiologyThe American journal of medicine
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A study of triplets with Hashimoto's thyroiditis
- MedicinePostgraduate medical journal
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The finding of Hashimoto's thyroiditis in identical triplets has not previously been reported and the cases of Faith, Hope and Charity, 63-year-old triplet sisters are presented.
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It is suggested that pernicious anemia may be an autoimmune disorder and the nature of the parietal cell autoantigen and the prevalence of gastric antibodies have been extended and the relationship between the different tests for intrinsic factor antibodies analyzed.
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