AUTOIMMUNITY IN PERNICIOUS ANEMIA AND THYROIDITIS: A FAMILY STUDY *

@article{Doniach1965AUTOIMMUNITYIP,
  title={AUTOIMMUNITY IN PERNICIOUS ANEMIA AND THYROIDITIS: A FAMILY STUDY *},
  author={Deborah Doniach and Ivan Maurice Roitt and K. B. Taylor},
  journal={Annals of the New York Academy of Sciences},
  year={1965},
  volume={124}
}
The familial occurrence of myxoedema and Hashimoto’s thyroiditis has been well documented (Craig et al . , 1952; Dunning, 1959; Kitchin & Howell-Evans, 1960; Irvine et al., 1961; Hung & Winship, 1963). Thyroid autoantibodies were found by Hall, Owen and Smart (1960) in 22 of 39 siblings of patients with autoimmune thyroid disease and no less than 11 of these had some clinical abnormality of the thyroid gland. I t was concluded that the tendency to thyroid autoimmunity was genetically determined… 

Autoimmunity and multiple endocrine abnormalities.

Binding studies carried out on a patient with chronic lymphocytic thyroiditis, idiopathic adrenal insufficiency, pernicious anemia, and vitiligo suggest that a genetically determined predisposition to develop autoimmune reactions of this type may exist in some individuals.

Autoantibodies in simple atrophic gastritis

Interesting correlations were found between the parietal cell antibodies and such factors as the degree of loss of parietal cells, the severity of the gastric secretory defect, and the presence of thyroid antibodies.

Early Onset of Pernicious Anaemia in Two Siblings: Genetic and Autoimmune Aspects

It is postulated that the presence of autoimmune disease in both sides of the family potentiated a genetic predisposition to autoimmune disease and the offspring developed pernicious anaemia at an unusually early age and had antibodies against several tissues and/or their products including thyroid tissue but no overt thyroid disease.

Juvenile pernicious anaemia.

  • S. Dimson
  • Medicine
    Archives of disease in childhood
  • 1966
Since hypocalcaemia is thought to depress gastric function and possibly also the secretion of intrinsic factor (Waters and Murphy, 1963), cases following endocrine disorders should be treated with reserve when conclusions are drawn regarding the nature of juvenile pernicious anaemia.

Pernicious Anaemia as an Autoimmune Disease

Over the last 20 years the megaloblastic anaemias has been one ofthe major fields ofresearch in the Department of Haematology at the Royal Postgraduate Medical School under the direction of Professor

Immunologic aspects of adrenocortical insufficiency.

Antineutrophil cytoplasmic antibodies in autoimmune thyroid disorders.

The aim of this study was to evaluate the presence of antineutrophil cytoplasmic antibodies (ANCA) in sera of patients affected by Graves' disease and Hashimoto's thyroiditis, and to investigate the reactivity against myeloperoxidase and lactoferrin.

Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability

The study of children with autoimmune gastritis and their families may provide additional insights into the disease’s pathogenesis and may also lead to the identification of inheritable factors influencing susceptibility.
...

References

SHOWING 1-10 OF 48 REFERENCES

AUTOIMMUNITY IN PERNICIOUS ANEMIA AND ATROPHIC GASTRITIS *

It is suggested that pernicious anemia may be an autoimmune disorder and the nature of the parietal cell autoantigen and the prevalence of gastric antibodies have been extended and the relationship between the different tests for intrinsic factor antibodies analyzed.

Autoimmune Phenomena in Pernicious Anaemia: Gastric Antibodies

The presence of an inhibitor of intrinsic factor activity was demonstrated in the sera of some patients with pernicious anaemia who had never been treated with hog intrinsic factor, and this supported the earlier suggestions, based upon the histological appearances of the gastric mucosa, that pernious anaemia might have an autoimmune component.

Familial Juvenile Pernicious Anaemia: A Study of the Hereditary Basis of Pernicious Anaemia

The present study reports the occurrence of juvede pernicious anaemia in two brothers, and its presumptive occurrence in a third brother, together with the results of 5Co-vitamin.

Autoantibodies in simple atrophic gastritis

Interesting correlations were found between the parietal cell antibodies and such factors as the degree of loss of parietal cells, the severity of the gastric secretory defect, and the presence of thyroid antibodies.

A Family Study of Pernicious Anaemia

Close relatives of patients with pernicious anaemia and their relatives were examined to find out more about the pattern of inheritance of pernitic anaemia, and to define more clearly, if it existed, thc ‘pre-pcrnicious Anaemia’ state.

Latent Pernicious Anaemia

Results of the follow-up study of 29 of the relatives of close relatives of patients with pernicious anaemia are reported, 17 of whom are classed as having latent pern Delicious anaemia.

Thyroid Auto-antibodies in Pernicious Anaemia

Examination of the serum of patients with pernicious anaemia for these antibodies was the most appropriate line of inquiry, and the electrophoretic method was found to be the most suitable for the study of this antibody.

Immunological Relationship Between Pernicious Anaemia and Thyroid Disease

In the small series of dyspeptics reported here administration of betamethasone phosphate solution controlled their symptoms as effectively as enteric-coated tablets, with the advantage of more effective control of the skin eruption.

A case of juvenile pernicious anemia: study of the effects of folic acid and vitamin B12.

The probable sequence of events in these patients from childhood to the development of anemia, usually in later life, is set forth, and the metabolic interrelationships of folic acid and vitamin B12 are discussed.