AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

@article{Anand2003AURORAAAO,
  title={AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.},
  author={Shubha Anand and Sue Penrhyn-Lowe and Ashok R. Venkitaraman},
  journal={Cancer cell},
  year={2003},
  volume={3 1},
  pages={51-62}
}
The serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. Here we show that elevated Aurora-A expression at levels that reflect cancer-associated gene amplification overrides the checkpoint mechanism that monitors mitotic spindle assembly, inducing resistance to the chemotherapeutic agent paclitaxel (Taxol). Cells overexpressing Aurora-A inappropriately enter anaphase despite defective spindle formation, and the persistence of Mad2 at the kinetochores, marking… CONTINUE READING

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