AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes.

@article{Sarkar2008AUF1IR,
  title={AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes.},
  author={Srijata Sarkar and Kristina S Sinsimer and Randi L Foster and Gary Brewer and Sidney Pestka},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2008},
  volume={28 11},
  pages={679-91}
}
IL-10 is an immunomodulatory cytokine that regulates inflammatory responses of mononuclear phagocytes (monocytes and macrophages). Mononuclear cells exposed to microbes or microbial products secrete a host of proinflammatory cytokines followed by delayed onset of anti-inflammatory IL-10. IL-10 suppresses immune responses by inhibiting cytokine production by mononuclear phagocytes. Using THP-1, a human promonocytic leukemia cell line, we show that endotoxin/lipopolysaccharide (LPS) exposure… CONTINUE READING

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Genome-wide analysis identifi

G Stoecklin, SA Tenenbaum, +5 authors P. Anderson
2008

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