AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation.

@article{Fan1997AUrichET,
  title={AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation.},
  author={Xinhao Cynthia Fan and Vic E. Myer and J. A. Steitz},
  journal={Genes & development},
  year={1997},
  volume={11 19},
  pages={2557-68}
}
AU-rich elements (AREs, usually containing repeated copies of AUUUA), when present in the 3'-untranslated regions (UTRs) of many mammalian mRNAs, confer instability on their host RNA molecules. The viral small nuclear RNA (snRNA) Herpesvirus saimiri U RNA 1 (HSUR 1) also contains an AUUUA-rich sequence. Here, we report that this ARE induces rapid degradation of HSUR 1 itself and of other snRNAs including HSUR 2 and cellular U1. Mutational analyses of the viral ARE establish that sequence… CONTINUE READING

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