AU-rich elements: characterization and importance in mRNA degradation.

  title={AU-rich elements: characterization and importance in mRNA degradation.},
  author={Chun-Ming Chen and A B Shyu},
  journal={Trends in biochemical sciences},
  volume={20 11},
Adenylate/uridylate-rich elements (AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors and cytokines. They represent the most common determinant of RNA stability in mammalian cells. Moreover, ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines and transcription inhibitors. These observations suggest that AREs play a critical role… CONTINUE READING
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