AU RNA-binding factors differ in their binding specificities and affinities.

@article{Bohjanen1992AURF,
  title={AU RNA-binding factors differ in their binding specificities and affinities.},
  author={Paul R. Bohjanen and Bronislawa Petryniak and Carl H June and Craig B Thompson and Tullia Lindsten},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 9},
  pages={6302-9}
}
AUUUA multimers present in the 3'-untranslated region of mature lymphokine and cytokine transcripts have been implicated in the regulation of mRNA stability and translational efficiency. We have identified RNA-binding factors, termed AU-A, AU-B, and AU-C, that interact with AUUUA multimers. AU-A is an abundant, constitutively expressed 34-kDa factor that localizes primarily to the nucleus. AU-A binds to AUUUA multimers with low relative affinity and also binds to other U-rich sequences… CONTINUE READING