ATTEMPTS: a heparin/protamine-based prodrug approach for delivery of thrombolytic drugs.

@article{Liang2001ATTEMPTSAH,
  title={ATTEMPTS: a heparin/protamine-based prodrug approach for delivery of thrombolytic drugs.},
  author={Jersey Liang and Yoon Jeong Park and Hui Song and Yong Li and Victor C Yang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={72 1-3},
  pages={145-56}
}
The aim of this study is to develop a heparin/protamine-based prodrug system for the controlled delivery of enzyme such as tissue-type plasminogen activator (tPA). This approach, termed antibody targeted, triggered, electrically modified prodrug-type strategy (ATTEMPTS), would permit antibody-directed administration of inactive tPA, and allow a subsequent triggered release of the active tPA at the target site. Cation-modified tPA (mtPA) was attached to a heparin--antifibrin complex via ionic… CONTINUE READING