ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.

Abstract

ATRX is a centromeric heterochromatin binding protein belonging to the SNF2 family of helicase/ATPases with chromatin remodeling activity. Mutations in the human ATRX gene result in X-linked alpha-thalassaemia with mental retardation (ATRX) syndrome and correlate with changes in methylation of repetitive DNA sequences. We show here that ATRX also functions… (More)

Topics

Cite this paper

@article{Fuente2004ATRXAM, title={ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.}, author={Rabindranath De La Fuente and Maria M Viveiros and Karen Wigglesworth and John J. Eppig}, journal={Developmental biology}, year={2004}, volume={272 1}, pages={1-14} }