ATR signaling can drive cells into senescence in the absence of DNA breaks.

@article{Toledo2008ATRSC,
  title={ATR signaling can drive cells into senescence in the absence of DNA breaks.},
  author={Luis Ignacio Toledo and Matilde Murga and Paula Gutierrez-Martinez and Rebeca Soria and Oscar Fern{\'a}ndez-Capetillo},
  journal={Genes & development},
  year={2008},
  volume={22 3},
  pages={297-302}
}
The ATR kinase is a key transducer of "replicative stress," the type of genomic damage that has been postulated to be induced by oncogenes. Here we describe a cellular system in which we can unleash ATR activity at will, in the absence of any actual damage or additional signaling pathways triggered by DNA breaks. We demonstrate that activating ATR is sufficient to promote cell cycle arrest and, if persistent, triggers p53-dependent but Ink4a/ARF-independent senescence. Moreover, we show that an… CONTINUE READING
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