ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation.

Abstract

Microcephaly and medulloblastoma may both result from mutations that compromise genomic stability. We report that ATR, which is mutated in the microcephalic disorder Seckel syndrome, sustains cerebellar growth by maintaining chromosomal integrity during postnatal neurogenesis. Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced… (More)

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@article{Lang2016ATRMC, title={ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation.}, author={Patrick Y Lang and Gouri J Nanjangud and Marina Sokolsky-Papkov and Christine I Shaw and Duhyeong Hwang and Joel S. Parker and Alexander V. Kabanov and Timothy R Gershon}, journal={Development}, year={2016}, volume={143 21}, pages={4038-4052} }