ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

@article{Brown2000ATRDL,
  title={ATR disruption leads to chromosomal fragmentation and early embryonic lethality.},
  author={Eric J. Brown and David Baltimore},
  journal={Genes & development},
  year={2000},
  volume={14 4},
  pages={397-402}
}
Although a small decrease in survival and increase in tumor incidence was observed in ATR(+/-) mice, ATR(-/-) embryos die early in development, subsequent to the blastocyst stage and prior to 7.5 days p.c. In culture, ATR(-/-) blastocysts cells continue to cycle into mitosis for 2 days but subsequently fail to expand and die of caspase-dependent apoptosis. Importantly, caspase-independent chromosome breaks are observed in ATR(-/-) cells prior to widespread apoptosis, implying that apoptosis is… CONTINUE READING
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