ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.

  title={ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.},
  author={Thiyam Ramsing Singh and Abdullah Mahmood Ali and Manikandan Paramasivam and Arun Pradhan and Kebola Wahengbam and Michael M. Seidman and Amom Ruhikanta Meetei},
  journal={Cancer research},
  volume={73 14},
Fanconi anemia (FA) is a genome instability syndrome that has been associated with both cancer predisposition and bone marrow failure. FA proteins are involved in cellular response to replication stress in which they coordinate DNA repair with DNA replication and cell-cycle progression. One regulator of the replication stress response is the ATP-dependent DNA translocase FANCM, which we have shown to be hyperphosphorylated in response to various genotoxic agents. However, the significance of… CONTINUE READING
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