ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitro.

@article{Weidanz2005ATRBR,
  title={ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitro.},
  author={Jon Weidanz and Lynn M. Jacobson and Rebecca J Muehrer and Arjang Djamali and Debra A. Hullett and Jenifer Sprague and M. Chiriva-Internati and Vaughan Wittman and Thomas J. Thekkumkara and Bryan N. Becker},
  journal={Kidney international},
  year={2005},
  volume={67 6},
  pages={2134-42}
}
BACKGROUND Type 1 angiotensin II (Ang II) receptor (AT(1)R) signaling induces proinflammatory responses. Recent studies suggest that T lymphocytes express AT(1)R; yet the effects of Ang II binding to AT(1)R on T cells are poorly understood. We examined the effect of AT(1)R blockade on release of the proinflammatory cytokine, interferon-gamma (IFN-gamma) by human lymphocytes in vivo and in vitro. METHODS We used an AT(1)R blocker losartan in a randomized clinical trial in kidney transplant… CONTINUE READING