ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.

@article{Chen2017ATRMP,
  title={ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.},
  author={C Chen and Rolando Ruiz-Vega and Priya Vasudeva and Francisco Espitia and Tatiana B. Krasieva and S{\'e}bastien M de Feraudy and Bruce J. Tromberg and Sharon K S Huang and Chad Garner and Jie Wu and Dave S B Hoon and Anand K. Ganesan},
  journal={Cell reports},
  year={2017},
  volume={18 10},
  pages={2331-2342}
}
Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA damage and is required for cellular proliferation. ATR mutant tumors exhibit both the accumulation of multiple mutations and the altered expression of inflammatory genes, resulting… CONTINUE READING

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