ATPase site architecture and helicase mechanism of an archaeal MCM.

  title={ATPase site architecture and helicase mechanism of an archaeal MCM.},
  author={Matthew J Moreau and Adam T. McGeoch and Alan R Lowe and Laura S. Itzhaki and Stephen D Bell},
  journal={Molecular cell},
  volume={28 2},
The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM complex, are members of the AAA+ (ATPase-associated with various cellular activities) family of ATPases. Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes. Here, we investigate the function of the AAA+ site in the mini-chromosome maintenance (MCM) complex of the archaeon Sulfolobus solfataricus (SsoMCM). We find that SsoMCM has an unusual… CONTINUE READING

From This Paper

Topics from this paper.
50 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…