ATPase site architecture and helicase mechanism of an archaeal MCM.

@article{Moreau2007ATPaseSA,
  title={ATPase site architecture and helicase mechanism of an archaeal MCM.},
  author={Matthew J Moreau and Adam T. McGeoch and Alan R Lowe and Laura S. Itzhaki and Stephen D Bell},
  journal={Molecular cell},
  year={2007},
  volume={28 2},
  pages={304-14}
}
The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM complex, are members of the AAA+ (ATPase-associated with various cellular activities) family of ATPases. Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes. Here, we investigate the function of the AAA+ site in the mini-chromosome maintenance (MCM) complex of the archaeon Sulfolobus solfataricus (SsoMCM). We find that SsoMCM has an unusual… CONTINUE READING

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