ATPase inhibitors of heat-shock protein 90, second season.

@article{Janin2010ATPaseIO,
  title={ATPase inhibitors of heat-shock protein 90, second season.},
  author={Yves L. Janin},
  journal={Drug discovery today},
  year={2010},
  volume={15 9-10},
  pages={342-53}
}
In the past four years, the ATP-dependent heat-shock protein 90 has remained the focus of much interest. Phase I and phase II anticancer clinical trials with first-generation inhibitors, although sometimes disappointing, have yet to report a forbidding side-effect inherent to the inhibition of this chaperone, which has a very complex and widespread role in… CONTINUE READING