ATPase activity and conformational changes in the regulation of actin.

@article{Schler2001ATPaseAA,
  title={ATPase activity and conformational changes in the regulation of actin.},
  author={Herwig Sch{\"u}ler},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1549 2},
  pages={137-47}
}
The eukaryotic microfilament system is regulated in part through the nucleotide- and cation-dependent conformation of the actin molecule. In this review, recent literature on the crystal and solution structures of actin and other actin-superfamily proteins is summarized. Furthermore, the structure of the nucleotide binding cleft is discussed in terms of the mechanism of ATP hydrolysis and P(i) release. Two distinct domain movements are suggested to participate in the regulation of actin. (1… CONTINUE READING