ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation

@inproceedings{Yabas2011ATP11cIC,
  title={ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation},
  author={Mehmet Yabas and Charis En-Yi Teh and Sandra Frankenreiter and Dennis Lal and Carla M. Roots and Belinda Whittle and Daniel T. Andrews and Yafei Zhang and Narci C-H Teoh and Jonathan Sprent and Lina E. Tze and Edyta Kucharska and Jennifer Kofler and Geoffrey C. Farell and Stefan Br{\"o}er and Christopher C. Goodnow and Anselm Enders},
  booktitle={Nature Immunology},
  year={2011}
}
Subcompartments of the plasma membrane are believed to be critical for lymphocyte responses, but few genetic tools are available to test their function. Here we describe a previously unknown X-linked B cell–deficiency syndrome in mice caused by mutations in Atp11c, which encodes a member of the P4 ATPase family thought to serve as 'flippases' that concentrate aminophospholipids in the cytoplasmic leaflet of cell membranes. Defective ATP11C resulted in a lower rate of phosphatidylserine… CONTINUE READING