ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.

@article{Arashiki2016ATP11CIA,
  title={ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.},
  author={Nobuto Arashiki and Yuichi Takakuwa and Narla Mohandas and John E. S. Hale and Kenichi Yoshida and Hiromi Ogura and Taiju Utsugisawa and Shouichi Ohga and Satoru Miyano and Seishi Ogawa and Seiji Kojima and Hitoshi Kanno},
  journal={Haematologica},
  year={2016},
  volume={101 5},
  pages={
          559-65
        }
}
Phosphatidylserine is localized exclusively to the inner leaflet of the membrane lipid bilayer of most cells, including erythrocytes. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized phosphatidylserine is a phagocytic signal for splenic macrophages. Flippases are P-IV ATPase family proteins that actively transport phosphatidylserine from the outer to inner leaflet. It has not yet been determined which of the 14 members of this family of… CONTINUE READING
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