ATP triggers a robust intracellular [Ca2+ ]-mediated signalling pathway in human synovial fibroblasts.

@article{Kondo2018ATPTA,
  title={ATP triggers a robust intracellular [Ca2+ ]-mediated signalling pathway in human synovial fibroblasts.},
  author={Chie Kondo and Robert Bradley Clark and Tae Youl Kim and Tae Yen Kim and Umberto Banderali and Robert T. Szerencsei and R T Szerencsei and Paul P M Schnetkamp and P P M Schnetkamp and K W Spitzer},
  journal={Experimental physiology},
  year={2018},
  volume={103 8},
  pages={
          1101-1122
        }
}
NEW FINDINGS What is the central question of this study? What are the main [Ca2+ ]i signalling pathways activated by ATP in human synovial fibroblasts? What is the main finding and its importance? In human synovial fibroblasts ATP acts through a linked G-protein (Gq ) and phospholipase C signalling mechanism to produce IP3 , which then markedly enhances release of Ca2+ from the endoplasmic reticulum. These results provide new information for the detection of early pathophysiology of arthritis… CONTINUE READING
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