ATP stimulates Ca2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices.

@article{Bergner2002ATPSC,
  title={ATP stimulates Ca2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices.},
  author={Albrecht Bergner and Michael J. Sanderson},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 6},
  pages={L1271-9}
}
In airway smooth muscle cells (SMCs) from mouse lung slices, > or =10 microM ATP induced Ca2+ oscillations that were accompanied by airway contraction. After approximately 1 min, the Ca2+ oscillations subsided and the airway relaxed. By contrast, > or =0.5 microM adenosine 5'-O-(3-thiotriphosphate) (nonhydrolyzable) induced Ca2+ oscillations in the SMCs and an associated airway contraction that persisted for >2 min. Adenosine 5'-O-(3-thiotriphosphate)-induced Ca2+ oscillations occurred in the… CONTINUE READING

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