ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload

Abstract

We set out to identify molecular mechanisms underlying the onset of necrotic Ca2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca2+ chelation and the cation channel blocker gadolinium. However, the surface permeability to Ca2+ was reduced by 60… (More)
DOI: 10.1038/sj.cdd.4401852

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Cite this paper

@article{Castro2006ATPSB, title={ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload}, author={J. Castro and Iv{\'a}n Ruminot and Omar H. Porras and Claudia Flores and Txomin Hermosilla and Eva Verdugo and Fabiola Venegas and S. Haertel and Luis Michea and Linda Barros}, journal={Cell Death and Differentiation}, year={2006}, volume={13}, pages={1675-1685} }