ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.

@article{Sarantopoulos2003ATPsensitivePC,
  title={ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.},
  author={Constantine D Sarantopoulos and Bruce McCallum and Damir Sapunar and Wai-Meng Kwok and Quinn H. Hogan},
  journal={Neuroscience letters},
  year={2003},
  volume={343 3},
  pages={185-9}
}
ATP-sensitive potassium (K(ATP)) currents were examined in dorsal root ganglion neurons from neuropathic and control rats using whole-cell voltage clamp recordings. K(ATP) channel openers (diazoxide and pinacidil) enhanced, and the blocker glibenclamide inhibited an outward current in control neurons in a manner dependent on the pipette ATP concentration. Analysis of reversal potentials showed that this current is carried by K(+) ions. Outward current in cells from rats with peripheral nerve… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…