ATP-sensitive potassium channels in health and disease.

  title={ATP-sensitive potassium channels in health and disease.},
  author={Rebecca Hawkins Clark and Peter Proks},
  journal={Advances in experimental medicine and biology},
The ATP-sensitive potassium (K(ATP)) channel plays a crucial role in insulin secretion and thus glucose homeostasis. K(ATP) channel activity in the pancreatic beta-cell is finely balanced; increased activity prevents insulin secretion, whereas reduced activity stimulates insulin release. The beta-cell metabolism tightly regulates K(ATP) channel gating, and if this coupling is perturbed, two distinct disease states can result. Diabetes occurs when the K(ATP) channel fails to close in response to… CONTINUE READING
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