ATP-sensitive potassium channels in adult mouse skeletal muscle: Different modes of blockage by internal cations, ATP and tolbutamide

@article{Woll1989ATPsensitivePC,
  title={ATP-sensitive potassium channels in adult mouse skeletal muscle: Different modes of blockage by internal cations, ATP and tolbutamide},
  author={Karl H. Woll and U. L{\"o}nnendonker and Berthold Neumcke},
  journal={Pfl{\"u}gers Archiv},
  year={1989},
  volume={414},
  pages={622-628}
}
Single ATP-sensitive K channels were studied in membrane patches excised from enzymatically dissociated mouse toe muscle. The channel conductance is 74 pS in symmetrical 160 mM KCl solutions. Replacement of K+ by Na+ in the internal solution or 2 mM internal Ca2+ or Mg2+ induced a rectification of the current-voltage curve at positive potentials. No change of the current-voltage curve was observed by adding small amounts of the channel blockers ATP (20–100 μM) or tolbutamide (0.5 mM) to… CONTINUE READING
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ATP sensitive K channels in adult mouse skeletal muscle

KH Woll
  • Neumcke B
  • 1988

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