ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.

@article{Akatsuka1994ATPSP,
  title={ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.},
  author={Yutaka Akatsuka and Kensuke Egashira and Yousuke Katsuda and Takahiro Narishige and Hitoshi Ueno and Hiroaki Shimokawa and Akira Takeshita},
  journal={Cardiovascular research},
  year={1994},
  volume={28 6},
  pages={906-11}
}
OBJECTIVE The aim was to determine a role of ATP sensitive potassium (KATP) channels in adenosine A2 receptor mediated coronary vasodilatation in anaesthetised dogs in vivo. METHODS Coronary blood flow in the left circumflex coronary artery, aortic pressure, and left ventricular pressure were measured during intracoronary infusions of the drugs into the left circumflex artery. RESULTS A non-selective A2 receptor agonist NECA (5'-N-ethylcarboxamidoadenosine) at 10(-10)-10(-8) mol.min-1… CONTINUE READING