ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo.

@article{Samaha1992ATPsensitivePC,
  title={ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo.},
  author={Fouad Samaha and Friedhelm Heineman and Can Ince and Jacqueline Fleming and Robert S Balaban},
  journal={The American journal of physiology},
  year={1992},
  volume={262 5 Pt 1},
  pages={C1220-7}
}
Glibenclamide, a known selective inhibitor of ATP-sensitive potassium channels, was infused into the coronary vasculature of anesthetized dogs and of isolated perfused rabbit hearts to assess the role of this channel in the maintenance of basal coronary resistance. Infusion of glibenclamide at a concentration of 55-80 microM in the dogs resulted in a twofold steady-state increase in coronary resistance with resultant tissue ischemia. Infusion of 1 microM glibenclamide in the isolated hearts… CONTINUE READING