ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes.

@article{Sim2002ATPsensitiveKC,
  title={ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes.},
  author={Jae Hoon Sim and Dong Ki Yang and Young Chul Kim and Sung Jin Park and Tong Mook Kang and Insuk So and Ki Young Kim},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 1},
  pages={
          G137-44
        }
}
This study was designed to identify the single-channel properties and molecular entity of ATP-sensitive K(+) (K(ATP)) channels in guinea pig gastric myocytes with patch-clamp recording and RT-PCR. Pinacidil and diazoxide activated K(ATP) currents in a glibenclamide-sensitive manner. The open probability of channels was enhanced by the application of 10 microM pinacidil from 0.085 +/- 0.04 to 0.20 +/- 0.05 (n = 7) and was completely blocked by 10 microM glibenclamide. Single-channel conductance… CONTINUE READING

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