ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions.

@article{Ashcroft1989ATPsensitiveKC,
  title={ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions.},
  author={Frances M. Ashcroft and Masafumi Kakei},
  journal={The Journal of physiology},
  year={1989},
  volume={416},
  pages={349-67}
}
1. The inside-out configuration of the patch-clamp method was used to study the effects of MgATP, free ATP and Mg2+ on single ATP-sensitive K+ channel currents in rat pancreatic beta-cells. 2. Magnesium ions caused a marked reduction of channel activity: 5 mM-free Mg2+ produced a 50% reduction in the activity of inward currents recorded at -60 mV in symmetrical K+ concentrations. 3. Inhibition of channel activity by MgATP does not involve phosphorylation as both free ATP (i.e. ATP in the… CONTINUE READING

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