ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.

@article{Alekseev2005ATPsensitiveKC,
  title={ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.},
  author={Alexey Alekseev and Denice M. Hodgson and Amy B. Karger and Sungjo Park and Leonid V. Zingman and Andre Terzic},
  journal={Journal of molecular and cellular cardiology},
  year={2005},
  volume={38 6},
  pages={895-905}
}
Cardiac ATP-sensitive K(+) (K(ATP)) channels, gated by cellular metabolism, are formed by association of the inwardly rectifying potassium channel Kir6.2, the potassium conducting subunit, and SUR2A, the ATP-binding cassette protein that serves as the regulatory subunit. Kir6.2 is the principal site of ATP-induced channel inhibition, while SUR2A regulates K(+) flux through adenine nucleotide binding and catalysis. The ATPase-driven conformations within the regulatory SUR2A subunit of the K(ATP… CONTINUE READING