ATP release and Ca2+ signalling by human bronchial epithelial cells following Alternaria aeroallergen exposure.


  Exposure of human bronchial epithelial (HBE) cells from normal and asthmatic subjects to extracts from Alternaria alternata evoked a rapid and sustained release of ATP with greater efficacy observed in epithelial cells from asthmatic patients. Previously, Alternaria allergens were shown to produce a sustained increase in intracellular Ca2+ concentration… (More)
DOI: 10.1113/jphysiol.2013.254649

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