ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells.

Abstract

Type I topoisomerases have been purified from nuclei and mitochondria of human acute lymphoblastic leukemia cells. Both of these ATP-independent enzymes are actually found to be inhibited by ATP at physiologically significant concentrations. Other adenine nucleotides showed varying effects: ADP inhibited only at high concentrations; AMP had no effect on… (More)

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@article{Castora1986ATPIN, title={ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells.}, author={Frank J. Castora and William G. Kelly}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1986}, volume={83 6}, pages={1680-4} }