ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9

@article{Choi2010ATPIM,
  title={ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9},
  author={M. Choi and Kyu Suk Cho and S. Shin and H. Ko and K. Kwon and C. Shin and K. Ko},
  journal={Archives of Pharmacal Research},
  year={2010},
  volume={33},
  pages={257-265}
}
In response to brain insults, microglia, the resident inflammatory cells in CNS, migrate into injured sites to initiate inflammatory responses in brain. ATP, released from apoptotic or necrotic cells induce chemoattractive responses but the mechanism is not clear yet. In this study, we investigated whether ATP modulates microglial migration by regulating the activity of matrix metalloproteinases (MMPs). ATP induced rapid microglial migration and increased the activity of MMP-9 in the culture… Expand
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