ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.

@article{Bickle1978ATPinducedCC,
  title={ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.},
  author={Thomas A. Bickle and Christine Brack and Robert Yuan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 7},
  pages={3099-103}
}
ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage. 
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