ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents.

@article{Wu2007ATPinducedCO,
  title={ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents.},
  author={Long-Jun Wu and Kunjumon I. Vadakkan and Min Zhuo},
  journal={Glia},
  year={2007},
  volume={55 8},
  pages={
          810-21
        }
}
Microglial cells are the resident macrophages that are involved in brain injuries and infections. Recent studies using transcranial two-photon microscopy have shown that ATP and P2Y receptors mediated rapid chemotactic responses of miroglia to local injury. However, the molecular mechanism for microglial chemotaxis toward ATP is still unknown. To address this question, we employed a combination of simultaneous perforated whole-cell recordings and time-lapse confocal imaging in GFP-labeled… CONTINUE READING
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