ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages.

Abstract

Macrophages express the P2X(7) receptor and other nucleotide (P2) receptors, and display the phenomenon of extracellular ATP (ATP(e))-induced P2X(7)-dependent membrane permeabilization, which occurs through a poorly understood mechanism. We used patch-clamp recordings, cytoplasmic Ca(2+) measurements and fluorescent dye uptake assays to compare P2X(7… (More)
DOI: 10.1242/jcs.029991

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