ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages.

@article{Burm2016ATPinducedIS,
  title={ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages.},
  author={Saskia Maria Burm and Ella Alwine Zuiderwijk-Sick and Paola Massiel Weert and Jeffrey J Bajramovic},
  journal={Glia},
  year={2016},
  volume={64 12},
  pages={2231-2246}
}
Under stressful conditions nucleotides are released from dying cells into the extracellular space, where they can bind to purinergic P2X and P2Y receptors. High concentrations of extracellular ATP in particular induce P2X7-mediated signaling, which leads to inflammasome activation. This in turn leads to the processing and secretion of pro-inflammatory… CONTINUE READING