ATP-induced ATP release from astrocytes.

  title={ATP-induced ATP release from astrocytes.},
  author={Christopher M Anderson and Jennifer P Bergher and Raymond A Swanson},
  journal={Journal of neurochemistry},
  volume={88 1},
Propagation of interastrocyte Ca2+ waves is mediated by diffusion of extracellular adenosine triphosphate (ATP), and may require regenerative release of ATP. The ability of ATP to initiate release of intracellular ATP was assessed by labeling adenine nucleotide pools in astrocyte cultures with 14C-adenine. The 14C-purines released during exposure to ATP were then identified by thin-layer chromatography. ATP treatment caused a five-fold increase in release of 14C-ATP but not 14C-ADP or 14C-AMP… CONTINUE READING
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