ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Abstract

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked to ATP binding and dimerization of its two nucleotide binding domains (NBDs). Channel activation also requires phosphorylation of the R domain by poorly understood mechanisms… (More)
DOI: 10.1073/pnas.0913001107

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@article{Wang2010ATPindependentCC, title={ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.}, author={Wei Wang and Jianping Wu and Karen Bernard and Ge Li and Guangyu Wang and Mark O. Bevensee and Kevin Kirk}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 8}, pages={3888-93} }